A.t.o.m. ps2 ps2#

Everything is mostly in Very Good condition, there is. Sarma.Īlzheimer’s disease dynamics membrane mutations presenilin 2. Action Man A.T.O.M Alpha Teens on Machines Sony Playstation 2 (PS2) Game. Remarkably, similar properties of the open state are known to impair the binding of substrates to γ-secretase, and we thus argue that the two mechanisms could be functionally related.Communicated by Ramaswamy H. The associated loss of compactness may also impair calcium affinity.

A.t.o.m. ps2 ps2#

We find that most pathogenic PS2 mutations significantly reduce stability relative to random mutations, using a statistical ANOVA test with all possible mutations in the affected sites as a control. TM2, TM6, TM7 and TM9 flexibility controls the size of this channel. We show that the nine-transmembrane channel structure is substantially controlled by major dynamics in the hydrophilic loop bridging TM6 and TM7, which functions as a 'plug' in the PS2 membrane channel. The models are based on cryo-electron microscopy structures of PS1 translated to PS2, augmented with missing residues and a complete all-atom membrane-water system, and equilibrated using three independent 500-ns simulations of molecular dynamics with a structure-balanced force field. Here, we develop a computational model of PS2 in the membrane to address the question how pathogenic PS2 mutations affect the membrane-embedded protein.

Most work so far has focused on PS1, but humans carry both PS1 and PS2, and mutations in both cause AD. Presenilins 1 and 2 (PS1 or PS2) are main genetic risk factors of familial Alzheimer's disease (AD) that produce the β-amyloid (Aβ) peptides and also have important stand-alone functions related to, e.g.